Elucidation of mechanisms of action of Wei-Sheng-Fang-Yi-Bao-Dan in the treatment of COVID-19 and depression using network pharmacology and molecular docking

Purpose: To investigate the mechanisms of action Wei-Sheng-Fang-Yi-Bao-Dan (WSFYBD) in treatment COVID-19 and depression using network pharmacology molecular docking.
 Methods: First, bioactive components target genes WSFYBD were retrieved from TCMSP database. The relevant gene targets obtained databases. core for separately by determining intersection. Cytoscape 3.8.0 software was used to draw visual interactive networks. STRING database employed construct protein-protein interaction networks, while Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) functional enrichment analyses determine function pathway via a Bioconductor/R. Finally, AutoDockTools Results: A total 105 potential bio-active 35 therapy identified. Also, 1905 GO entries (p < 0.05) 158 related signal pathways obtained. Similarly, 114 127 therapeutic Moreover, 1948 177 0.05). Docking results showed main closely bound targets.
 Conclusion: treating show that directly acts on SARS-CoV-2 virus prevent it entering host cell, or inhibits replication. Secondly, ameliorates acting key control over-activated cytokines. Therefore, has potentials management depression.